Lecture 5
ثبت نشده
چکیده
While the machinery of quantitative genetics can blissfully function in complete ignorance of any of the underlying genetic details, we are certainly interested (at least one some level) on the genetic basis of trait variation. At the most practical level, if a gene of major effect is segregating in our population of interest, we would certainly like to not only to be aware of this, but also to fine map it for future exploration/exploitation. Often no single locus contributes more than a fraction of the total genetic variation in a trait. In such cases, we often use the term polygene for one of these loci of small effect. The (still evolving) more modern use is to call these genes quantitative trait loci, or simply QTL or QTLs for short. Lecture 8 deals with statistical approaches for QTL mapping, while we focus here first on the genetic basis of quantitative trait variation, and then on methods for first detecting and then fine mapping genes of large effect. Included as a special case of the later are so-called candidate genes, loci for which we have biological information to suggest that they may contribution variation to the trait of interest.
منابع مشابه
Math 140a: Foundations of Real Analysis I
1. Ordered Sets, Ordered Fields, and Completeness 1 1.1. Lecture 1: January 5, 2016 1 1.2. Lecture 2: January 7, 2016 4 1.3. Lecture 3: January 11, 2016 7 1.4. Lecture 4: January 14, 2014 9 2. Sequences and Limits 13 2.1. Lecture 5: January 19, 2016 13 2.2. Lecture 6: January 21, 2016 15 2.3. Lecture 7: January 26, 2016 18 2.4. Lecture 8: January 28, 2016 21 3. Extensions of R: the Extended Rea...
متن کاملThe Effect of Lecture in comparison with Lecture and Problem Based Learning on Nursing Students Self-Efficacy in Najafabad Islamic Azad University
Introduction: Self-efficacy has an important role in applying scientific and professional knowledge and skills. Teaching methods can develop different skills such as decision making capability. The aim of this study was to determine the effect of teaching method of lecture in comparison with lecture and problem based learning on nursing students self-efficacy in Najafabad Islamic Azad Universit...
متن کاملNonperturbative Quantum Field Theory on the Lattice
These lectures provide an introduction to lattice methods for nonperturbative studies of quantum field theories, with an emphasis on Quantum Chromodynamics. Lecture 1 (Ch. 2): gauge field basics; lecture 2 (Ch. 3): Abelian duality with a lattice regulator; (Ch. 4) simple lattice intuition; lecture 3 (Ch. 5): standard methods (and results) for hadron spectroscopy; lecture 4 (Ch. 6): bare actions...
متن کاملLectures on Linear Systems Theory
Part A. Analysis in the Time Domain . . . . . . . . . . . . . . 2 Lecture 1. RC circuits ...................... . 2 Lecture 2. From RC circuits to linear systems ............. 8 Lecture 3. Impulse and impulse response ............... . . 14 Lecture 4. Complex numbers .................... 22 Lecture 5. RCL circuits ..................... . 30 Lecture 6. RCL circuits, convolution, simple composite...
متن کاملMath 145a Lecture Notes
1 September 2, 2014 5 1.1 Broad Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.2 Introduction to Independence . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.3 Example of Independence . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.4 More Surprising Examples . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 1.5 Escaping . . . . . . . . . . . ....
متن کامل